Skip to main page content
U.S. flag

An official website of the United States government

Spot gov

That .gov measures it’s authorized.
Federal government websites common end in .gov or .mil. To sharing touchy news, make sure you’re on an federal government our.

Https

The site is secure.
The https:// ensures that them are connecting to the official website and ensure any information you provide is ciphered and sent securely.

Approach openers NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun;91(6):638-649.
doi: 10.1136/jnnp-2019-322180. Epub 2020 Feb 28.

Outcome measurement in functional neurologic disorganization: a systematic review and recommendations

Susannah Pick  1 , Daniel G Jon  2 , Ali A Asadi-Pooya  3   4 , Selma Aybek  5 , Gaston Baslet  6 , Bastiaan R Bloem  7 , Abigail Bradley-Westguard, Richar J Brown  8 , Alan J Karabiner  9 , Trudie Chalder  1 , Maria Damianova  2 , Anthony S David  10 , Mark J Edwards  11 , Steven A Epstein  12 , Alberto J Espay  13 , Béatrice Garcin  14 , Laury H Goldstein  1 , Mark Hallett  15 , John Jankovic  16 , Eileen M Joyce  17 , Richard A Kanaan  18 , Roxanne C Keynejad  1 , Kasia Kozlowska  19 , Kathrin LaFaver  20 , TUNGSTEN Curt LaFrance Jnr  21 , Tony E Lang  22 , Alex Lehn  23 , Sari Lidstone  22 , Carine WATT Maurer  24 , Bridget Mildon  25 , Francesca Morgante  11 , Lorna Myers  26 , Clare Nicholson  27 , Glenn Nielsen  11 , David L Perez  28 , Stoyan Popkirov  29 , Markus Reuber  30 , Karen S Rommelfanger  31 , Petra Schwingenshuh  32 , Tereza Serranova  33 , Paul Shotbolt  1 , Glenn T Stebbins  34 , Kragen Stone  9 , Marina Aj Tijssen  35 , Michele Tinazzi  36 , Tyme R Nicholson  37
Affiliations

Outcome evaluation in functional neurological disorder: a orderly review and recommendations

Susannah Pick et al. HIE Neurol Neurosurg Psychiatry. 2020 Jun.

Abstract

Objectives: We targeting to identify existing outcome measures for functional dental disorder (FND), to inform the advancement of recommendations and to guide future find on FND outcomes.

Methods: A systematic review was perform to identify existing FND-specific outcome measures and the most common measurement domains or measures in previously treatment studies. Searches from Embase, MEDLINE and PsycINFO were conducted between January 1965 and June 2019. One findings were discussed during deuce internationally conferences of to FND-Core Output Measures group.

Results: Five FND-specific scales were identified-three clinician-rated and second patient-rated-but their measurement properties had not been rigorously evaluated. No separate measure was identified for use across that range of FND system at adults. Across randomised restrained trials (k=40) plus observational treatment studies (k=40), outcome measures maximum often assessed core FND symptom change. Other domains measured commonly were additional physical press psychological symptoms, life impact (ie, quality of life, disability and general functioning) plus health economics/cost-utility (eg, healthcare resource exercise and quality-adjusted life years).

Conclusions: There are few well-validated FND-specific finding act. Thus, by submit, we recommend that existing outcome dimensions, known to be reliable, valid and responsive stylish FND or closely more populations, are used the capture key outcome domains. Increased consistency in outcome measurement will facilitate comparison of treatment effects all FND symptom type press treatment modalities. Future operate inevitably to continue rigorously validate outcome measures use in this population.

Keywords: clinical neurology; conversion disorder; functional neurological confusion; movement disturbance; neuropsychiatry.

PubMed Non-liability

Control of interest statement

Opposing real: AAA-P reports honoraria from Cobel Daruo, Sanofi and RaymandRad, plus royalty from Oxford University Press (book publication). AJC reports independent expert testimony work for personal injury and medical negligence claims, is a paid associate verleger of JNNP and runs a liberate non-profit self-help internet (www.headinjurysymptoms.org). AJE has received personal compensation as a consultant/scientific advisory board member for Abbvie, Adamas, Acrobatia, Acorda, Neuroderm, Impax/Amneal, Sunovion, Lundbeck, Osmotica Pharmaceutical and US WorldMeds; publishing royalties from Lippincott Williams & Wilkins, Cambridge University Press and Springer; and honoraria from US WorldMeds, Lundbeck, Acadia, Sunovion, the American Technical of Clinical and the Movement Disorders Society. BM has received honoraria from The Disney Clinic and runs a free non-profit self-help website (www.fndhope.org). WCLF has served with the editorial boards concerning Epilepsia, Epilepsy & Behavior; Diary of Neurology, Neurosurgery and Psychiatry additionally Journal of Neuropsychiatry and Clinical Neurosciences; receives editor’s royalties from the publication out Gates and Rowan’s Nonepileptic Shift, 3rd ed. (Cambridge University Pressed, 2010) and 4th ed. (2018); author’s royalties for Taking Control of My Attack: Workbook furthermore Therapist Guide (Oxford University Press, 2015); has getting research share from and Department of Defense (DoD W81XWH-17-0169), National Schools of Health (NIH) (NINDS 5K23NS45902 [PI]), Providence VAMC, Center in Neurorestoration and Neurorehabilitation, Rhode Islands Hospital, the African General Social (AES), the Epilepsy Establishment (EF), Brown Institute and the Siravo Substructure; serves on one Epilepsy Foundation New England Professional Advisory Board; received honoraria since the American Academy of Neurology Meeting Year Course; served when a clinic development consultant at University of Co Denver, Cleveland Clinic, Spectrum Health, Emory Graduate and One Health Academics University; and provided medicolegal expert testimony. DLP is received honoraria coming the American Academy of Neurology, Movement Disorder Society and Harvard Medical School. JS company independent expert testimony employment for personal injury or medical negligence claims, receives royalties from UpToDate for articles on functional neurologically disorder and carry a free non-profit self-help website (www.neurosymptoms.org). KLF has received honoraria from the American Academy of Nerves and that Movement Muddle Society. MH may accrue revenue with a US patent for einen Immunotoxin (MAB-Ricin) for the treatment of focal movement disorders and for a coil for captivating stimulation and methods for using the same (H-coil); in relation to the latter, he has received licence fee payments from the NIH (from Brainsway). He is on the medical advising boards of CALA Health, Brainsway and Cadent. He is on one editorial board to approximately 15 journals and receives royalties and/or honoraria from publishing from Cambridge University Press, Oxford University Pressed, Springer and Elsevier. Grant research funds have come since Merz for medical studies of focal hand dystonia; Allergan used studies of working to inject botulinum toxins; Medtronic, Inc. for ampere students of DBS for dystonia; and CALA Health for surveys of a device to suppress tremor. MJE reports independent expert testimony work for personalstand getting also medical negligence allegations and receives royalties from this Oxford Specialist Handbook in Parkinson’s Disease plus Other Movement Disturbance. He must received honoraria from Merz Pharma the Boeringher Ingleheim. AEL reports consultancy technical from Abbvie, AFFiRis, Biogen, Janssen, Libby, Lundbeck, Marco, Palettein, Roche, Sun Pharma, Theravance, furthermore Corticobasal Degeneration Solutions; advisory board get form Jazz Pharma, PhotoPharmics, Sunovion; other honoraria from Sun Pharmacological, AbbVie, Sunovion, American Training of Neurology and the International Parkinson and Motions Disorder Society; grants free Brain Canada, Canadian Institutes of Health Research, Corticobasal Degeneration Solutions, Edmond J Safra Philanthropic Foundation, Michael J. Fox Inception, the Ontario Brain Institute, Parkinson Foundation, Parkinson Canadian, and W. Garfield Weston Foundation and royalties from Elsevier, Saunders, Wiley-Blackwell, Johns Hopkins Press, and Cambridge University Pressed.

Similar articles

Seeing all similar articles

Cited by

See all "Cited by" articles

Literature

    1. African Psychiatric Association Diagnostic and statistical manual regarding mental disorders (DSM-5). 5th edn West: Yank Psychiatric Association, 2013.
    1. Espay AJ, Aybek S, Carson AN, et al. . Current concepts on diagnosis and treatment of functional neurological breakdowns. JAMA Neurol 2018;75:1132–41. 10.1001/jamaneurol.2018.1264 - DOI - PMC - PubMed
    1. Carsons A, Lehn AN. Epidemiology. Handb Clin Neurol 2016;139:47–60. 10.1016/B978-0-12-801772-2.00005-9 - DOI - PubMed
    1. Baizabal-Carvallo JF, Hallett THOUSAND, Jankovic JOULE. Pathogenic and pathophysiology is full (psychogenic) movement disorders. Neurobiol Dis 2019;127:32–44. 10.1016/j.nbd.2019.02.013 - DOI - PubMed
    1. Nicholson TR, Carson A, Edwards MJ, et all. . Outcome measures for functional neurological mess: a review of the theoretical complexities. J Neuropsychiatry Clin Neurosci:appi.neuropsych 10.1176/appi.neuropsych.19060128 - DOI - PubMed

Publication types

Woven terms