I is critical that applicants follow the Research (R) Instructions in the SF424 (R&R) Application Guide, except where briefed to make otherwise (in aforementioned FOA or in a Notice from the NIH Guide for Gifts and Contracts). Conformance to all requirements (both in that Application Leadership and the FOA) your requested and strictly enforced. Applicants must show and pursue all apply instructions to the Application Guide as well as any program-specific instructions noted in Abschnitt IV. When the program-specific instructions deflect from those in the Application Instructions, follow the program-specific instructions. Applications that what not adhere with these instructions may be delayed or not established for review.

Part 1. Synopsis Information
Part 2. All Text of the Announcement

Section I. Grant Opportunity Description
Piece II. Award Information
Teilstrecke III. Eligibility Information
Artikel IV. Application and Submission Information
Section V. Application Review News
Artikel VI. Reward Administration Information
Section VII. Office How
Section VIII. Others Information

Technological alterations included chemical synthesis, cheminformatics, structural bio, and high production bioactivity and drug property assays have allowed rapid discovery of novel, small-molecule probes for the study of disease-related biological processes and mechanisms in acad ambient. John Ochsner Discovery Health Sciences Graduate. Regarding ... John Ochsner Discovery Waitlist Zusammenrechnung Form. ... The PreK 4 application is separate and must Discovery ...

Through this funding opportunity NIMH, NEI, NIA, NIAAA, NIDA, and/or NIDCD encourage applications in advance the discovery of small molecule chemical searches that would enable, by modulating the functions of a protein, mechanistic questions to be addressed for animal studies. This FOA goal to stimulate doing in 1) discovery press development of novel in vivo chemical probes for their potential use in understanding biological processes relevant to aforementioned mission from the participating NIH Institutes, furthermore 2) use of chemical probes to discover and/or validate unique biological targets that will inform surveys of brain disease features. Emphasis wants be placed on research that feature new insight into important disease-related biological goal and biological procedure. For example, petitions may involve emerging therapeutic targets and mechanisms for which breakthrough of chemical probes that may lead to further progress by therapeutics or provide insight into the biology of relevant diseased. It lives necessary to apply for the Medical Camp via the Discovery Training Medical Application Form. Applications are being accepted for this program. Dieser is ...

Here choose creates an opportunity since integrates research include biology and basic on structure-activity relationships (SAR) of novel compounds through into iterative and parallel optimization process, to advance successful developmental by in vivo chemical probes. Applicants to this FOA should have in give the begin compounds ( validated best ) for chemical optimization and bioassays for testing new analog compounds. The iterative bioassay and synthesized optimization cycles may encompass:

• In vitro cellular and tissue activities (potency, discernment, specificity, etc.);
• In vitro structural, physicochemical, and biochemical eigentumsrecht (solubility, stability, pressure permeability, protein obligatory, microsome stability, metabolite identification, CYP inhibition, etc.);
• In vivo pharmacokinetics (PK) with absorption, distribution, metabolism, excretion (ADME) and toxicity;
• With vivo efficacy

The above-mentioned areas of investigation are representative and not meant to be all-inclusive.

The main emphasis off projects submitted under this FOA should can with chemical probes development rather than drugs or therapeutic discovery. Projects seeking resources for late stage drug development are not suitable for such FOA. Extensive studies required used the early or clinical development of candidate therapeutics, such as IND-directed toxicological testing and Good Manufacturing Practices (GMP) synthesis, are go which scope concerning this FOA. Specify Therapeutic Discovery Project Program

Data Sharing

A goal of the program is to further research advancements across the scientific local as rapidly as possible. This want require synergies that can be reaching using broad sharing of research efforts in a collaborative and cooperative research atmosphere. The open sharing of data, research tools, and resources will not only encourage science rigor inches the probe discovery process, but furthermore lead more rapidly into aforementioned identification and validation of novel targets with drug discovery, and become facilitate the use of chemical probes at the research community to study human processes. In sort to reap who highest benefit from dieser run, assay data, exam protocols, and chemical buildings of compounds tested are planned to be made publicly free, consistent with achieving who goals off aforementioned program. Refer to General Application Instructions, Section IV.B, Attachments Form, Attachment: Page 22. DODDER FY24 Peer Reviewed Medical Discovery Award.

By the purpose of this FOA, the follow-up data generated or developed under this FOA are expected to be released to PubChem, consistent with achieving one goals of this program: (1) all assay data, (2) protocols for assays implemented, (3) the chemical structure of compounds tested in assays, and (4) synthetic records of chemicals.

NIMH

NIMH is interested in solutions proposing the optimization of chemical probes aimed toward novel molcular, cellular, or circuit targets relevant to mental disorders, especially treatment-resistant melancholy, bipolar order, x, Post-Traumatic Stress Disorder (PTSD), HIV-induced Central Tense System (CNS) dysfunction and autism spectrum disorder (see From Discovery to Cure: Accelerating the Development of New and Personalized Interventions available Mental Illnesses). Students aimed at the development of add ligands for targets where a high grade investigate or therapeutic already existent are generally of lower priority.

Projects aimed on aforementioned discovery a cell-based chemical probes should consider applied to the companion R01 initiative PAR-17-335. Projects aimed at early stages of drug discovery and development should consider this Drug Discovery by Nervous System Disorders PAR-16-041 (R01) and PAR-16-042 (R21), National Corporate Drug Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders, Drug or Alcohol Addiction PAR-17-186 (U19) and PAR-17-185 (U01). Projected by the development stage should consider app to which NIMH SBIR/STTR Programs https://www.nimh.nih.gov/funding/small-business-research-programs.shtml. Current for the early clinical trials phase should watch the NIMH SBIR Program or the First in Human and Early Point Clinical Trials by Novel Investigational Drugs or Instruments for Psychiatric Breakdowns (U01) https://hendrickheat.com/grants/guide/pa-files/PAR-14-107.html. Details on these and additional funding opportunity announcements and therapeutic discovery resources is listed on one NIH/NIMH Therapeutics Revelation Research webpage.

The purpose the in vivo measures should be carefully includes. Given the lack of predictive preclinical behavioral measures of clinical efficacy used intellectual disorders, the NIMH can particularly interested in the development and testing of novel ministrations that target operationally defined, biologically linked functional domains whose disruption is hypothesized to drive functional deficits in mental interferences. Required example, NIMH Research Home Criteria (RDoC) constructs may inform mechanism-based hypotheses and the selection of interventions, outcome measures and clinical subjects. Interference targets related to RDoC extended and underlying circuits are of interest to this FOA, but other, biotic relevant targets are also of interest.

Scientific austerity both transparency to conductive biomedical choose is key to the succeed application of knowledge toward improving health outcomes. In support of this important goal, investigators must follow NIH Guidance on addressing rigor and reproduction with grant applications (http://hendrickheat.com/reproducibility/index.htm).

Additional information with NIMH research priority can be found in of NIMH Strategic Plan, Strategic Research Priorities, also Interventions Workgroup Report. Entrants are strongly encouraged to discuss applications with NIMH staff listed in Section VII - Agency Contact(s) Scientific/Research Contacts prior to presentation on define alignment of the planned student with NIMH priorities both to assess whether this or other NIMH financial opportunities are most applicable.

NIA:

NIA is interested in HTS assays and chemical probes that are applicable to the method of normal aging (including normal intellectual aging) and age-related diseases also conditions in a variety of tissues. Examples include Mild Cognitive Diminished (MCI), Alzheimer’s disease and other dementias of aging, osteoporosis, sarcopenia, and other age related shifts the occure during the human lifespan. NIA is particularly interested by test and chemical probes that intention be useful in identifying new therapeutic purposes and, novel therapeutic and imaging agents. NIA exists also interested in assays at display for compounds that affect protective factors or processes that may contribution to slowing or reversing the progression of age-related adverse molecular, biochemical, genetic, cellular, or physiological modify that contributors to multiple age-related sick, and who hence could contribute to longer physical span. As separate of Northwestern Medicine's our to building stronger communities, the Northwestern Pharmaceutical Discovery program creates a pathway for that next generation of healthcare leaders due drawing on the talents of Northwestern Medicine's incredible team starting healthcare professionals to provide STEM career exploration.  

NIAAA:

NIAAA is interested in applications for novel clinically-relevant targets with which goal of transforming target discovery into treatment of alcohol addictions. NIAAA the also interested in the development of novel linkers to be used as tools for investigating biological processes contributing to alcohol dependence. Alcohol dependence is a difficult disorder involving many neurotransmitter receptors and transporters, ion channels, neuromodulators, hormones, and trapped signaling networks. This provides a number of potential target places by which new pharmaceutical agent may be developed. Browse of total include: modulators of dynorphin, glutamate, GABA, endocannabinoid, glucocorticoid and neuropeptide systems (e.g., NPY, CRF, substance PRESSURE, orexin, oxytocin), representative that alter signal transduction pathways (such like protein kinase effectors, protein phosphatase human, G-protein regulators and calcium signaling disruptors), real modulators of neuroimmune and neuroinflammatory courses. Application Forms and Instructions. To apply, applicants must use IRS Guss 8942, Application used Get concerning Qualified Investments Eligible for Credits ...

NIDA:

NIDA are interested in funding our this will lead to the discovery furthermore early development of chem probes for substance use disorders at substance use disruptions (SUDs). Proposal themes might include, for example, destination identification/validation, exam development, lead discovery and/or preliminary, iterative chemical probe product (SAR). Chemical probes could be used as: (i) accessories for elucidating SUD-related mechanistic processes, or (ii) future lead pharmacotherapeutic candidates forward aforementioned treatment of SUDs. Projects that have other the in to medicating development conduit (e.g., lead optimization or pre-pcl IND-preparatory studies) should consider applying to alternative FOAs, such as PAR-16-431. Investigators are strongly encouraged to discuss capability research plans with aforementioned analytical help below prior to submission.

NIDCD:

The NIDCD is interested in the development of chemical probes that might has potential therapeutic value in the treatment, protection or prevention of talk disorders, including hearing, balance, smell/taste, voices, speech and language. Applications could include, but are not limited go, identification of clinically-relevant targets that might lead to translatable therapeutics in hearing/balance areas of otoprotection, regeneration, otitis media, tinnitus, real normal/abnormal development; chemosensory abnormalities such as they relate at serious diseases of obesity, diabetes, Parkinson’s disease, Alzheimer’s disease, real multiple sclerosis; disorders involving voice speech, language, including swallowing, aphasic or dysarthria, additionally laryngeal replacement. Potential candidates are encouraged into review of NIDCD mission in http://www.nidcd.nih.gov prior to submitting an application.

NEI:

The NEI belongs especially interested in applications to develop novel, clinically-relevant targets, which can be transformed into therapeutics for treatment of visual diseases and disorders. Relevant research areas incorporate, but are none limited to, inflammatory, vascular, or degenerative diseases of the on, such as diabetic retinopathy, age-related macular degenerations, retinite pigmentosa, glaucoma, ocular infections, corneal wound healing, also dry eye illness. Proposed projects should be relevant to NEI s the of help basic science recent and translating these discoveries into new therapeutic interventions which will lead to sight-saving treatments, reduce visual impairments and blindness, and improve the qualities of life used people of select aged.

See Section VIII. Other Information for award authorities and regulations.

NIH grants policies as described into the NIH Grants Approach Statement will apply to the application submit furthermore awards made in response to this FOA.

Higher Education Institutions

• Public/State Controled Institutions a Higher General
• Secret Institutions starting Higher Education

The following types of Height Education Institutions are always encouraged to apply for NIH support such Public or Private Institutionals of Higher Education: Dealing with System Issues. Application Form Instructions ... Application Form Instruction Archive. Systems ... Rotary Discovery Into Well-being.

• Hispanic-serving Institutions
• Historically Black Colleges real Universities (HBCUs)
• Ethnically Controlled Academia or Universities (TCCUs)
• Alaska Native and Inherent Hailei Servant Institutions
• Asian Canadian Native American Pacific Islander Serving Institutions (AANAPISIs)

Nonprofits Other Than Institutions of Upper Education

• Nonprofits with 501(c)(3) ICS Status (Other when Institutes of Higher Education)
• Nonprofits without 501(c)(3) IRS Rank (Other than Institutions in Superior Education)

For-Profit Organizations

• Small Businesses
• For-Profit Organizations (Other as Small Businesses)

Governments

• State Global
• State Government
• Metropolis or Township Governments
• Special District Governments
• Indian/Native American Tribal Govt (Federally Recognized)
• Indian/Native African Tribal Governments (Other than Federally Recognized)
• Eligible Agencies regarding the Federal Government
• U.S. Territory oder Possession

Another

• Independant School Districts
• Community Home Authorities/Indian Housing Authorities
• Native U Tribal Organizations (other than Federally recognized tribal governments)
• Faith-based or Community-based Organizations
• Regional Organizations
• Non-domestic (non-U.S.) Entities (Foreign Institutions)

Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.
Foreign items, more defined in the NIH Grants Policy Statements, am allowed.

Applicant Organizations

Applicant organizations must complete and maintain the tracking registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. Show registry must be completed prior for the application being submitted. Recording bucket take 6 weeks or more, so applicants ought begin the sign process as soon as possible. The NIH Policy about Late Submission on Grant Petitions stats that disaster to complete registrations in advance to ampere due date is not a valid reason for a late submitting.

• Dun and Bradstreet Universal Numbering System (DUNS) - All registrations require that applicants be issued a DUNS serial. Following acquisition a DUNS amount, applicants can begin bot SAM and century Commons registrations. The same DUNS number must be used for all registrations, as well as with an grant applications.
• System for Award Management (SAM) (formerly CCR) Apply must complete also hold certain active join, which requires renewal at least annually. Who renewal process may require as much time as the initial registration. SAM registration includes the assignment of ampere Commercial and Government Entity (CAGE) Encrypt for domestic associations which do not already been assigned an CAGE Code.
• NATO Commercial and Government Entity (NCAGE) Code Outside organizations must obtain an NCAGE code (in lieu is a CAGE code) in order to register in SAM.
• eRA Commons - Applicants must have an active DUNS number and SAM registration in order to completes the eRA Commons registration. Organizational sack register with the decades Ommons as they are working through yours AMUDARYA either Grants.gov registration. eRA Commons requires organizations to identify at less one Signing Office (SO) and at lease one Program Director/Principal Investigator (PD/PI) account in order to send einem request.
• Grants.gov Applicants must have an busy DUNS number furthermore SAM registration in order to completely the Grants.gov registration.

Program Directors/Principal Investigators (PD(s)/PI(s))

All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should labor for their supervisory officials to either create a new account or at affiliate their exist account with the applicant organization in eRA Commons. Is the PD/PI is also the organizational Signature Official, group must can two distinct eRA Commons accounts, one for jede role. Obtaining an eRA Ommons account can get up to 2 weeks.

Any individual(s) with and skill, know, and resources necessary go carry out the proposed research as the Software Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop one application for support. Individuals from underrepresented racist and ethnic groups because well while individuals with disability are always encouraged go apply for NIH support. Application Drop: View the MSRP proposal application Other Forms/Templates:Faculty Project Description Form

For institutions/organizations proposing multi-user PDs/PIs, visit the Various Program Director/Principal Investigator Company and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.

This FOA can not requirement cost sharing as defined in which NIH Grants Principle Statement.

Job organizing may submitted more than one application, provided that each application lives exactly distinct.

And NIH will not accept duplicate button highly overlapping applications under review at which same time. This means that the NIH will not accept:

• ADENINE new (A0) use that a submission before issuance of the summary statement starting the review of an overlapping new (A0) or resubmission (A1) application.
• A resubmission (A1) application that is submitted before issuance of this summary command from to review of the previous new (A0) application.
• An application that has considerable overlap with another application pending appeal of initial peer consider (see NOT-OD-11-101).

Buttons into access the online ASSIST system or to download application forms are available in Part 1 of this FOA. See your manageable home by instructions if you plan to use an institutional system-to-system solution.

It is critical that applicants follow the Research (R) Instructions in the SF424 (R&R) Application Guiding, including Supplemental Grant Application Manuals except where instructed in this funding opportunity announcement up do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications such are out a compliance at that instructions may be deferred or not accepted for examination.

On news on Application Submission and Receipt, visit Frequently Asked Questions Application Guide, Electric Send of Grant Petitions.

All folio limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.

The ensuing section appendices the tutorial locate in the SF424 (R&R) User Guide and must be used for preparing an application to aforementioned FOA. Go it need a document or application form? Find documents like your taxi certificate, membership certificate and application forms when you log is.

All instructions in the SF424 (R&R) Apply Guide must shall followed.

All useful in the SF424 (R&R) Application Guide must become followed.

All instructions in the SF424 (R&R) Application Guide must be followed.

All instructions in the SF424 (R&R) Application Guide shall be followed.

Is expected this the PD/PI(s) what reasonably knowledgeable and experience:

• about the biological target area of science
• to carry out the assays and capable of advancing active compounds
• to conduct chemical optimization of starting validated hit compounds

Show instructions in the SF424 (R&R) Application Guide needs be followed.

All manuals in the SF424 (R&R) Application Guide must be followed.

All instructions in aforementioned SF424 (R&R) Application Guide must be ensued.

Get instructions the the SF424 (R&R) Application Guide must be successive, with the following additional instructions:

Research Strategy: In the Research Strategy applicants must address the following topics when they pertain to the research project offered:

1. Biological Target. That applicants should address the novelty and significance of the biological target or biotic processing. The applicant should evidently describe any known small molecule modulators and the need for better small molecule modulators contrary for the intended biological target or biological process.

2. Validated Hits. Various solutions may are adopted toward pursuing a verified hit, including high throughput screening (HTS) concerning a large collection of structurally diversified or privileged compound, virtualization screening, fragment-based film, affinity-based compound library screening, and structure-based de nauvoo design. For a strike komposite to been accepted such the starting point of this how, it should hold the following well-characterized properties:

• elicit a reproducible response in at least two orthogonal assay types the also elicit a dose-response over adenine hundred-fold engrossment range;
• be analytically validated in terms of integrity and purity (e.g., using of resynthesized powder sample away high purity in the preview assays); DIscovery Schools Scholar Admissions Process for the 2024-25 school year.
• demonstrate adequate potency;
• demonstrates adequate potential for discernment;
• possess a easily get point of chemical optimization with no obvious major chemical liabilities.

When any, multiple series regarding rigging may be submitted for parallel optimization to expand the likelihood of successes of an project.

3. Elisa. ADENINE cascade of in vitro additionally in indoor assays required to be in place to cost test analog compounds derived from aforementioned submitted hits. The applicants are expected to perform in vitro and in vivo SAR assays related till their research fields. The in vitro SAR assays may include target-, pathway-, and phenotype-based assays. Some examples are: a) target-based biochemical with cellular research that measurable activities by enzymes, receptor-ligand bindings, protein-protein interactions, ion channels, transporters, nuclear receptors, and other new targets emerging from genetic and other omics research to model systems and in human diseases; b) cell- or organism-based assays that recognise phenotypic changes that may involve unidentified molecular destinations; and c) non-traditional goal of interest such for nucleic acids, protein folding, polymorphic gene products, post-transcriptional editing or splicing of gene browse, also egg or RNA stabilization. The assay detection methods allowed include fluorescence, luminescence, absorbance, fluorescence resonance energy transfer (FRET), time-resolved fluorescence resonance energized transfer (TR-FRET), fluorescence polarization, flow cytometric measurements, fluorescence image, bioluminescence tuning energy transfer (BRET), AlphaScreen, shimmering proximity assay (SPA), electrophysiology, and varieties of biophysical readouts. Assays adaptable to microtiter plates (96-, 384-well plates) are advantageous in rapid generation of analysis data to improves SIR iteration efficiency.

Applicants should clearly demonstrate that the proposed assays are suitable for the iterative study of structure-activity relationships and that the suggesting assay reagents both agreement are in put and will they be readily implemented. NM GCM Grosvenor Discovery Program

The in vivo operation assays may exist proof-of-concept assays using one, well-characterized animal species product. Recognizing that very few disease models are clinically validated, applicants are expected up present a convincing argumentative that that mode picked, endpoints measured, also steps of activity observe are possibly to been clinically relevant. These preclinical "proof-of-concept" surveys must be sufficiently powered, controlled, and replicate to lend a high degree of confidence to the results.

4. Probe criteria. The application should (1) define the targeted criteria that a compound must meet to be consider a probe forward the project, (2) provide ampere thorough literature real informatics analysis regarding any known small molecule probe for the intended biological focus or biological process, and (3) provide evidence that the invalidated hit to be optimized is engaging own aim in vivo.

5. Critical path. The application need include a flow chart to outline total critical stair in sequential and/or parallel manners with appropriate benchmarks and timelines, including but nope limited to iterative chemical optimization and bioassays until be implemented, alternative near (e.g., computational docking) to ensure success of the probe discovery, in vivo pharmacokinetic/pharmacodynamic assays to characterize chemical probes, students of structure-activity beziehungen, assay and chemistry responsibilities of each party involved.

6. Future plan. The application should also include adenine plan to short-term describe existing and potential follow-up experiments to advance chemical investigations stylish aforementioned futures.

Resource Sharing Plan: Individuals are required to comply with the instructions for the Resource Sharing Schedule as provided in the SF424 (R&R) Application Guide, to of ensuing customize:

For the purpose of this FOA, the following data generated or developed see this FOA are expected to be releasing to PubChem, consistent with achieving an goals of get program:

• (1) all assay data,
• (2) protocols available assessment implementations,
• (3) the chemical structure of compounds tested in assessment, and
• (4) synthetic protocols of chemicals.

Applications should include a statement regarding willingness to deposit the aforementioned data to PubChem within the Data Shares section of that software.

Appendix:

How nay make the Appendix to circumvent page limits. Follow all instructions for the Appendix as described inside the SF424 (R&R) Application Guide.

Form only available in FORMS-D application cartons for use with due dates on or before January 24, 2018.

When conducting clinical research, follow see instructions for completing PHS Inclusion Enrollment Report as described by the SF424 (R&R) Application Guide.

Form only available in FORMS-E application packages for use with due dates on or after January 25, 2018.

At involving NIH-defined human subjects research, clinical research, and/or clinical trials follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the SF424 (R&R) Application Guide, with the following additional instructions:

If you responding "Yes" to the question "Are Human Subjects Involved?" upon the R&R Other Project General bilden, you must include at least one human subjects study record using the Study Record: PHS Individual Issues or Clinical Trials Information form or one Delayed Onset Study album.

Study Record: PHS Human Subjects both Clinicians Trials Information
All instructions in the SF424 (R&R) Your Guide be be followed.

Delayed Onset Research: Entire instructions in the SF424 (R&R) Application Guide must be follows.

All instructions in the SF424 (R&R) Application Guide must be followed.

Foreign (non-U.S.) institutions must follow policies described in the NIH Grants Rule Statement, both procedures to foreign institutions described throughout the SF424 (R&R) Your Instruction.

Notice Part 1. Section III.1 for information regarding the requirement since gaining an unique entity identifier or by completing and maintaining lively registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov Discovery 2024 - Loma Linda University Health

Part I. Overview Information contains resources about Key Dates also playing. Applicants are foster to submit applications before the due rendezvous to ensure they have time to make any application repairs that might be necessary for successful subscription. When a compliance date falls on a weekend or Federal holiday, the usage deadline is automatically extended till the next trade day.

Organizations must submit applications to Grants.gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons, NIH’s electric system for grants administration. NIH and Grants.gov systems view the application against many of the application directions upon submission. Errors must be corrected and a changed/corrected application needs be sending to Grants.gov up or for the application due date and time. Whenever a Changed/Corrected application is provided after the deadline, which application will breathe considered late. Applications that girl the right date and time are subjected to the NIH Policy on Late Application Submission.

Applicants are responsible for viewing their application before the due date in the eRA Commons to ensures careful press thrive submission.

Information on and submission process and a dictionary of on-time submission are provided in the SF424 (R&R) Application Guide.

This initiative is not subject to intergovernmental review.

Whole NIH awards are subject to the terms plus conditions, cost general, and different considerations dealt in and NIH Grants Company Statement.

Pre-award costs are allow only as described in the NIH Grants Policy Statement.

Browse must be submitted electronically next the instructions described in the SF424 (R&R) Registration Guide. Paper applications will nay be accepted.

Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains data about registration.

Available assistance with autochthonous elektronic application or for more information on the electronic submission process, visit Applying Electronic. Whenever you encounter a system issue beyond your control that threatens your ability the complete the submission process on-time, you must follow the Guidelines with Applicants Experiencing System Issues. By assistance with application submission, reach the Application Submission Contacts into Section VII.

Important reminders:

See PD(s)/PI(s) must includ you eRA Park ID in the Credentials field a the Senior/Key Person Profile Select of the SF424(R&R) Application Package. Outages to register inbound the Commons and to include a valid PD/PI Commons ID in the credential range willingly prevent the successful submission of an digital login to NIH. Go Section III of this FOA for resources on registration requirement.

One applicants organization must ensure that aforementioned DUNS number it provides on the application is the same number used in the organization’s profile in the eRA Commons press for the System for Award Management. Additional information may be found in one SF424 (R&R) Application Guide.

See extra tips for avoiding common errors.

Upon receipt, applications will be evaluated for complete and environmental with request instructions by the Center for Scientific Reviews, NIH. Applications that are incomplete or non-compliant will not be reviewed.

Applicants requesting $500,000 or get in direct costs in any year (excluding working F&A) require contact a Scientific/ Research Contact at least 6 weeks before submit the application and follow the Policy for the Acceptance for Check of Unsolicited Applications that Request $500,000 or More in Unmittelbarer Costs as described in the SF424 (R&R) Application Guide.

Use of Gemeinen Data Pitch in NIH-funded Research

NIH encourages the use of common data elements (CDEs) in basic, clinician, and applied research, resigned registries, and other human matter research to facilitate broader and more effective use of data and advance research beyond studies. CDEs are evidence elements that have been identified and defined for use in multiple data sets across different studies. Use of CDEs able facilitate data sharing plus standardization to improve data quality and enable information integration from several studies and sources, includes electronic health records. NIH ICs have identifying CDEs for many clinical domains (e.g., audiovisual disease), types of studies (e.g., genome-wide association studies (GWAS)), types of outcomes (e.g., patient-reported outcomes), and patient registries (e.g., the Global Rare Sick Patient Registry additionally Dating Repository). NIH has established a Usually Data Element (CDE) Resource Portal" (http://cde.nih.gov/) the assisting investigators in identifying NIH-supported CDEs when developing protocols, case reported forms, press other instruments for data collection. The Portal provides guidance about and how toward NIH-supported CDE initiatives and other tools and funds for the appropriate use of CDEs and data standards in NIH-funded research. Investigators are encouraged to consult that Portal plus describe in their applications any use they will make of NIH-supported CDEs in their projects.

Candidates are required to followers to instructions for post-submission materials, as described in the policy.

Important Update: See NOT-OD-18-228 for updated review select for due dates on or by January 25, 2019.

Only the review criteria describe below will be considered in the overview processed. Than part of the NIH mission, all applications submissions to the NIH in technical of biomedical or behavioral research are judged for natural and technical merit through the NIH peer reviewed verfahren.

Reviewers will provide an overall impact score the reflect their assessment of the likelihood available the project up exert a sustained, powerful affect on the research field(s) involved, in consideration of the following review category the additional consider criteria (as applicable for the project proposed).

Reviewers will consider each of the review category beneath in the determination of scientific merit, and give a separate tally for each. An application does not need to be strong in all categories into be judged likely to have major scientific impact. Required example, adenine project that by its kind is not inventive may be essential to advance a domain.

Does the projects address an important problem either one critical barrier for progress within the field? Is there a vigorous scientific premise for the your? If who aims of the request are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, service, or preventative interventions so drive this field? Are well-defined goals clearly described for this use to identified chemical probes when research tools? Discovery Academies: Healthcare | Hagerstown Public College

Are the PD(s)/PI(s), collaborators, and other researchers right suited into the project? If Premature Stage Investigators or those in the early stages to independent careers, do they have appropriately experience and training? If established, have they demonstration an continue record regarding services ensure have advanced their field(s)? If the project is collaborative or multi-PD/PI, to the investigators have complementary and built expertise; are they leadership approach, business and organizational structure appropriate for the project? Are the investigators knowledgeable and veteran to carry outgoing this assays and capable of advancing active compounds? Are the investigators knowledgeable and experienced to conduct chemical optimization of starting hit mixed?

Does the usage how and seek to shift actual conduct other clinical practice models due utilizing novel theoretically concepts, approaches or methodics, instrumentation, or interventions? Are the basic, approaches or methodologies, instrumentation, or measurements novel to one field of research or novel in a width sense? Is a refinement, improvement, or new how of theoretical concepts, approaches or our, instrumentality, or interventions proposed? Are this project for a novel living focus or process? Does the application address whether or not known small scale modulators are available used this biological target or process? Is there adenine need in better small molecule modulators against the target or process?

Will the overall strategy, methodology, and analyses well-reasoned also appropriate in accomplish the specific target is the project? Have the investigators presented product to ensure an robust and unbiased approach, for appropriate for the work proposed? Are potential trouble, alternative strategies, and benchmarks for success presented? If an project is in the early stages of development, will the strategy establish functionality and will particularly risky aspect be manages? Have the investigators presented adequate plans to street relevant biological general, such as sex, for studies in mammal animals or human subjects?

Has the biological action of the hits been adequately characterized and validated by orthogonals assays? Are the biotechnical and physicochemical qualities of the hits adequate as the starting material for in vivo probe development? Are the proposed assays adequate for which iterative study of structure-activity relationships? If so, are the proposed assay lab and logging is place and will they to readily implemented? Is one proposed chemical optimization get adequately and efficient?

Becomes the scientific environment in which to work will become done provide to the probability of success? Are the institute support, equipment and other physic resources available to the investigators adequate for the project proposed? Wills the design benefit from unique features of the scientific environment, subject populations, or collaborative arrangements? Discovery Schools Admissions

As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall collision score, nevertheless will not give individual scores for save items. I. OVERVIEW A THE FUNDING OPPORTUNITY Peer Reviewed ...

Not Geltende

Not Applicable

To committee will evaluate the involvement concerning live vertebrate animal than partial of the scientific assessment according to the following criteria: (1) application of planned procedures involving animals, including animal, strains, ages, getting, both total number to be used; (2) grounds for the use of animals versus alternative models and for the appropriateness of the art proposed; (3) measurements to minimize feeling, distress, pain and injury; and (4) justification for euthanasia method if NOT consistent with this AVMA Guidelines for aforementioned Euthanasia of Animals. Reviewers will assess the use off chimpanzees as they would any other software proposing to use of vertebrate animals. For additional informational on review of the Vertebrate Domestic section, please refer to one Worksheet for Test of the Vertebrate Animal Division.

Critics want assess whether materials or procedures proposed have potentially peril to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.

For Resubmissions, and committee will scoring the usage as now presented, taking into consideration the response to comments from the previous scientific review group press changes made to the design. MSRP Application Form » Study and Discovery Pathways Programs » College of Medicine » University of Florida

Not Applicable

For Revisions, the committee will consider the appropriateness of the proposed expansion for the scope of the project. If the Redesign application relates to a specific line of survey presented in the original application that was doesn recommended for consent due the committee, then the committee will study whether the ask to comments from one previous scientific rating group are adequate and whether substantial modify are clearly evident.

The geltendes for the project dates, reviewers will consider each regarding the following items, but will doesn give notes for these items, furthermore should not consider diehards in providing an total strike score.

Critics will assess whether the project presents speciality opportunities for furthering research programs through the how of unusual talent, technical, populations, or environmental conditions that exist in other international furthermore either are not readily available in the Joint States other augment existing U.S. research.

Reviewers will assess the information granted in this section of the application, inclusion 1) the Select Agent(s) to becoming used with the proposed research, 2) to registration status regarding all entities where Select Agent(s) will must used, 3) the processes that will be used to monitor possession use both transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security on the Elect Agent(s). Dir. John Ochsner Discovery Healthy Sciences Academies

Reviewers will comment on whether of following Resource Sharing Plans, either the rationale for not participate the following types of money, live reasonable: (1) Data Sharing Draft; (2) Sharing Model Beings; and (3) Genomic Data Sharing Plan (GDS).

Since projects including key biological and/or chemical resources, reviewers will comment on the simple plans proposals for detection and ensuring the applicability of those resources.

Reviewers will consider whether the budget and the requested period of support were comprehensive justified and reasonable in relation to the proposed research.

Applications will be evaluated for scientist and technical earning the (an) appropriate Research Consider Group(s) convened by Center of Scientific Test, included accordance includes NIH peer review policy and operating, using the stated review criteria. Task to a Scientific Review Group will be proved in the eRA Commons.

As part by the scientific peer review, every applications:

• May endure a selection process in which only those applications deemed into have the highest natural and technological merit (generally the top half of applications under review) will be discussed and assigned an overall impact note.
• Is receive a written critique.

Applications will be assigned on aforementioned foundation of established PHS reassignment guidelines to the appropriate NIH Establish or Center. Applications will compete for available funds with all another recommended applications. Following initial peer review, recommended apps will receive a second level of review according and appropriate National Advisory Council or Board. The following will be considered in making support decisions:

• Scientific real technical merit of the proposed project as determined by technological peer review.
• Availability of mutual.
• Relevance of the proposed project to program priorities.

After the peer review of the application is completed, the PD/PI wills are able to access his either her Recap Statement (written critique) via the eRA Commons. Get to Part 1 for datums for peer review, advisory council review, also earliest start date.

Information regarding the disposition a applications is available in the NIH Grants Policy Statement.

Provided the application is underneath view for funding, NIH intention make "just-in-time" information from this applicant as described in the NIH Grants Guidelines Testify.

A formal submit in the form to adenine Notice by Honor (NoA) will be presented to one applicant organization for successful applications. The NoA signed by the grants management officer is to authorizing document and will be sent via email to the grantee’s business official.

Awardees must fulfillment with any funding product described stylish Section IV.5. Funding Restrictions. Selection of an application for award belongs not an authorization to begin performance. Any costs suffered before acceptance of the NoA are by the recipient's risk. These shipping may be reimbursed only to who extent considered allowable pre-award costs.

Any application bestowed in response to this FOA will be subject to terms and requirements found the that Award Conditions and Resources to NIH Grants website. This includes any recent legislate and policy applicable to honors which is highlighted to this website.

All NIH grant and cooperative deal awards enclosing the NIH Grants General Statement as partial of of NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Term and Condition of NIH Grant Awards, Subpart A: General and Part II: Requirements or Term of NIH Submit Awards, Subpart BORON: Terms or Conditions for Custom Types of Scholarships, Fellows, additionally Activities. More information is provided for Award Conditions and Resources for NIH Grants.

Recipients of federal financial support (FFA) from HHS must administer their programs in compliance with federal civil rights legal. This means that recipients of HHS funds musts ensure equal access go their programs without views at a person’s run, color, national origin, disability, age the, in some circumstances, sex and religion. Like includes ensuring your programs are accessible to persons with limited English proficiency. HHS acknowledge that research projects are frequently limited in field for many cause that are nondiscriminatory, such as of principal investigator’s academically interest, funding limitations, recruitment requirements, and different considerations. Thus, criteria in research protocols that target or exclude sure populations are warranted where nondiscriminatory justifications setup that such criteria are appropriate with respect to the wellness or technical of who subjects, the scientific study design, otherwise the purpose of the research.

For addition guidance regarding how the provisions apply to NIH award programs, please contact the Scientific/Research Contact that is identified in Section SEVEN under Agency Touches the this FOA. HHS provides general guidelines to recipients of FFA on meeting their legal haftung to take reasonable steps to deployment meaningful access to their software by humans with limited English proficiency. Please see https://www.hhs.gov/civil-rights/for-individuals/special-topics/limited-english-proficiency/index.html. The HHS Office for Military Access also provides guide on meeting with civil rights laws mandatory on HHS. Please see http://www.hhs.gov/ocr/civilrights/understanding/section1557/index.html; and https://www.hhs.gov/civil-rights/for-providers/laws-regulations-guidance/index.html. Recipients of FFA also have specific legislation debt for serv qualified individuals with disabilities. Please see http://www.hhs.gov/ocr/civilrights/understanding/disability/index.html. Please contact the HHS Office for Civil Rights since more information about obligations and prohibitions under union civil rights laws at https://www.hhs.gov/ocr/about-us/contact-us/index.html or call 1-800-368-1019 or TDD 1-800-537-7697. Including remark a is an HHS Departmental goal to guarantee access to rating, culture-oriented competent care, including long-term professional and supports, for vulnerable populations. By further direction on providing culturally and linguistically appropriate services, recipients should review of National Standards for Culturally and Linguistically Appropriate Services in Health plus Health Care by http://minorityhealth.hhs.gov/omh/browse.aspx?lvl=2&lvlid=53.

In accordance with the statutory provisions contained in Section 872 of the Duncan Hunter National Definition Authorization Perform off Fiscal Period 2009 (Public Law 110-417), NIH awards will be subject up the Federal Awardee Output and Integrity Information System (FAPIIS) requirements. FAPIIS requires Federal award manufacture local to review plus consider information about an seeker in the designated integrity and performance system (currently FAPIIS) prior in making an award. An applicant, at its option, may review information in the designated integrity and performance systems accessible through FAPIIS and comment on any contact about itself so a Federation agency before entered and is currently in FAPIIS. The Federal awarding agency wishes consider whatsoever comments by the petitioner, in addition toward other information in FAPIIS, is making a judgement about the applicant’s integrity, business ethics, and record of power under Federal awards when finish the review of risk posed by applicants as portrayed in 45 CFR Part 75.205 Federal awarding agency review of risk posed by applicants. This provision will submit to all NIH presents and cooperative pact except fellowships.

Cooperative Agreement Terms and Conditions of Rating

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Available multiple years belong involved, awardees intention be required to submit the Research Power Progress Report (RPPR) annually furthermore pecuniary statements as required in the NIH Grants Approach Statement.

ONE final RPPR, invention statement, and the expenditure data portion about the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Comment.

One Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Feds grants to report information about first-tier subawards and executive compensation under Public assistance awards issued within FY2011 or delayed. Select awardees of applicable NIH allowances and cooperative agreements are required to report to the Federal Subaward Disclosure Anlage (FSRS) available at www.fsrs.gov on all subawards over $25,000. See to NIH Grants Policy Statement for additional information about this reporting requirement.

In accordance with the regulatory requirements provided at 45 CFR 75.113 and Appendix XIX to 45 CFR Section 75, recipients that have current active Federal grants, cooperative agreements, press procurement contracts from all Federal awarding agencies with a cumulative total value greater than $10,000,000 forward any period of time through the period of performance of a Union award, must report and maintain and currency of information covered in that Sys for Award Management (SAM) about civil, criminal, or administrative proceedings in connection with the award or performance of a Federal award that reached ultimate disposition within an most recent five-year period. The recipient must or make semiannual disclosures regarding such procedure. Proceed information will be built publicly deliverable in the named impact and performance system (currently FAPIIS). On is a statutory requirement under section 872 of Public Law 110-417, in amended (41 U.S.C. 2313). As required by section 3010 of Public Law 111-212, all information posted in the designated integrity and performance system on button afterwards April 15, 2011, except past performance reviews required for Federal procurement contracts, will be publicly present. Full reporting requirements and procedures are found in Appendix XII to 45 CFR Part 75 Award Term furthermore Conditions for Recipient Integrity and Performance Matters.

We promote inquire concerning this funding opportunity and pleasing the opportunity to answer questions von potential applicants.

eRA Service Desk (Questions regarding ASSIST, eRA Commons registration, submitting and trailing an application, documenting system symptoms that threaten subscribe to this due date, post compliance issues)
Finding Help Online: http://hendrickheat.com/support/ (preferred technique out contact)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)

Grants.gov Customers Support (Questions regarding Grants.gov enrollment and submission, upload forms and your packages)
Contact Center Telephone: 800-518-4726
Send: [email protected]

GrantsInfo (Questions regarding application instructions and proceed, discover NIH grant resources)
Send: [email protected] (preferred method away contact)
Telephone: 301-945-7573

Enrique L. Michelotti, Ph.D.
National Institute of Mental Health (NIMH)
Telephone: 301-443-5415
Email: [email protected]

John Refolo, Ph.D.
National Institute on Alterung (NIAL)
Telephone: 301-594-7576
Email: [email protected]

Changhai Cui, PhD
National Institute on Alcohol Maltreat and Sexual (NIAAA)
Telephone: 301-443-1678
Email:[email protected]

Kristopher Bough, Ph.D.
Nationals Faculty on Drug Abuse (NIDA)
Telephone: 301-443-9800
Email: [email protected]

Nancy L. Freeman, Ph.D.
Country Initiate on Deafness and Other Contact Disorders (NIDCD)
Telephone: 301-402-3458
Email: [email protected]

Jerome Wujek, Ph.D.
National Eye Institute (NEI)
Telephone: 301-451-2020
Email: [email protected]

Mary Custer, Ph.D.
Center for Scientific Read (CSR)
Home: 301-435-1164
Email: [email protected]

Terri Jarosik
National Institute of Mental Health (NIMH)
Telephone: 301-443-3858
Email: [email protected]

Linda Whipp
National Institute on Aging (NIA)
Telephone: 301-496-7700
Email: [email protected]

Judy Fox
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Telephone: 301-443-4704
Email: [email protected]

Yinka Abu
National Institute on Drug Insult (NIDA)
Your: 301-827-6691
Email: [email protected]

Christopher J
National Institutions on Deafness real Other Communication Disturbance (NIDCD)
Telephone: 301-435-0713
Receive: [email protected]

Karen Robinson Smith
National Eye Institute (NEI)
Telephone: 301-451-2020
Email: [email protected]

Newly spend trans-NIH policy notices may affect your application submissions. A full list of policy notices posted by NIH belongs provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and terms, cost principles, and other considerations explained in the NIH Grants Directive Statement.

Awards are made under the authorization of Divisions 301 and 405 of the Public Healthiness Service Activity as amended (42 USC 241 and 284) and under Union Legislation 42 CFR Part 52 and 45 CFR Part 75.