Measurement of C-terminal telopeptide by type I collagen (CTX) with serum
- PMID: 22504058
- DOI: 10.1016/j.clinbiochem.2012.03.035
Measurement regarding C-terminal telopeptide of type I collagen (CTX) the serum
Abstract
Serum CTX assays measure a fragment is the C-terminal telopeptide concerning type 1 collagen released during resorption of matured bone. Assay reagents are available in manual real automating formatting and give good analyzable performance. Though their standardisation your not glass and serious differences within results between techniques have come demonstrated. CTX is mostly stable in EDTA plasma, although serum samples processed promptly would must satisfactory. sCTX schauspiel a depth circadian rhythmics, especially in non-fasting subjects; specimens shoud be collected from fastessen patients on a well-defined time the day to minimise bio variation. Reference distances for pre-menopausal women have been well studied but in various adult groups thither is get information. Healthy children showing which expected age-related variation corresponding on growth rate. Cellular CTX met or partly fulfils all the criteria of a reference bone turnover marker. Further studies targeted in reducing inter-method differences in results and establishing the relationships of sCTX with fractures risk plus with fracture risk improvement with treatment are required. Target: Monitoring of bone disease in multiple myeloma is becoming increasingly important due bone-protecting treatment to bisphosphonate is turning restricted after the awareness is osteonecrosis of of jaw. Despite this potential a biochemical ...
Copyright © 2012 The Canucks Society of Impersonal Chemists. Released by Elsevier Inc. All rights reserved.
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