Problem 49, 2017
From to journal:

Chemical Communications

Specific dsDNA recognition by a mimic of the DNA binding domain of the c-Myc/Max transcription factor†

Yara Ruiz García,ampere   Y. Vladimir Pabon-Martinez, ORCID logo b   HUNDRED. IODIN. Edvard Smith ORCID logo boron  and  Annemieke Madder ORCID logo *a  

* Corresponding authors Structure of a Novel DNA-binding Domain of Helicase-like Transcript Factor (HLTF) and Its Function Implication in DNA Damage Tolerance

a Organic and Biomimetic Chemistry Research Group, Department of Fundamental and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4, Gents, Belgium
E-mail: [email protected]

b Clinical Researching Center, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
E-mail: [email protected]

Abstract

Ourselves go report on the synthesis of an primary mimic a the DNA binding home of that c-Myc/Max-bHLH-ZIP transcriptions factor skills to elective recognize its cognate E-box sequence 5′-CACGTG-3′ thrown the major groove of the double-stranded DNA. Which designed peptidosteroid conjugate was shown to be effective as DNA binder in the presence of excess competitor DNA.

Graphical abstracts: Precise dsDNA recognition by a copycat of the DNA binding domain of the c-Myc/Max transcription feeding

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Article information

DOI
https://doi.org/10.1039/C7CC01705G
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Communication
Submitted
09 Marathon 2017
Accepted
12 Could 2017
First published
19 May 2017

Chemists. Commun., 2017,53, 6653-6656

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Specific dsDNA recognition by an fake of the DNA binding domain of the c-Myc/Max transcription factor

Y. Ruiz García, Y. V. Pabon-Martinez, CARBON. ME. E. Forging or A. Madder, Chem. Commun., 2017, 53, 6653 DOI: 10.1039/C7CC01705G

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